Nurse practitioner pay in St. Louis, MO
Nurse practitioners in the St. Louis, MO-IL metro area earn a typical $131,580 a year. The middle half earn $127,460 to $154,500, and the top 10% earn more than $164,280. About 3,430 people do this job there.
Source: BLS Occupational Employment and Wage Statistics, May 2025 (occupation: Nurse Practitioners, SOC 29-1171).
Pay range
| Bottom 10% earn less than | $108,340 |
| 25th percentile | $127,460 |
| Median (typical) | $131,580 |
| 75th percentile | $154,500 |
| Top 10% earn more than | $164,280 |
Typical pay here ranks No. 29 of 50 large metros for nurse practitioners before taxes and prices.
After taxes and cost of living
At the typical $131,580, a single filer keeps about $94,600 a year after federal, Social Security, Medicare, and Missouri state and local (about $1,316) income tax. Prices in St. Louis are 5% below the US average, so that take-home buys what $99,500 would in a typical US city. That ranks St. Louis No. 18 of 50 large metros for nurse practitioners after cost of living.
Where nurse practitioners’ pay goes furthest
- San Jose, CA$231,560 typical · worth $139k
- San Francisco, CA$219,080 typical · worth $127k
- Sacramento, CA$172,010 typical · worth $110k
- Las Vegas, NV$144,060 typical · worth $110k
All 50 metros for nurse practitioners →
Where does your salary land?
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Common questions
How much does a nurse practitioner make in St. Louis, MO?
The typical (median) nurse practitioner in the St. Louis, MO-IL metro area earns $131,580 a year. The middle half earn between $127,460 and $154,500, and the top 10% earn more than $164,280. Source: BLS Occupational Employment and Wage Statistics, May 2025.
What is a good salary for a nurse practitioner in St. Louis?
Anything above $131,580 pays more than half of nurse practitioners in St. Louis. $154,500 or more puts you in the top quarter, and $164,280 in the top 10%. Experience and employer move where you should be in that range.
How much does a nurse practitioner in St. Louis take home after taxes?
At the typical $131,580, a single filer keeps about $94,600 a year ($7,890 a month) after federal, Social Security, Medicare, Missouri state, and local income tax. With local prices 5% below the US average, that buys what $99,500 would in a typical US city.
Where do nurse practitioners get paid the most after cost of living?
Among the 50 largest US metros, typical nurse practitioner pay goes furthest after taxes and prices in San Jose, CA, San Francisco, CA, Sacramento, CA. St. Louis, MO ranks No. 18.
More: Nurse practitioner pay in every large metro · Pay for other jobs in St. Louis, MO
Local prices: BEA regional price parities, 2024. Updated November 2026.