Medical assistant pay in St. Louis, MO
Medical assistants in the St. Louis, MO-IL metro area earn a typical $44,710 a year. The middle half earn $38,550 to $47,600, and the top 10% earn more than $48,620. About 6,170 people do this job there.
Source: BLS Occupational Employment and Wage Statistics, May 2025 (occupation: Medical Assistants, SOC 31-9092).
Pay range
| Bottom 10% earn less than | $36,670 |
| 25th percentile | $38,550 |
| Median (typical) | $44,710 |
| 75th percentile | $47,600 |
| Top 10% earn more than | $48,620 |
Typical pay here ranks No. 29 of 50 large metros for medical assistants before taxes and prices.
After taxes and cost of living
At the typical $44,710, a single filer keeps about $36,500 a year after federal, Social Security, Medicare, and Missouri state and local (about $447) income tax. Prices in St. Louis are 5% below the US average, so that take-home buys what $38,400 would in a typical US city. That ranks St. Louis No. 14 of 50 large metros for medical assistants after cost of living.
Where medical assistants’ pay goes furthest
- Sacramento, CA$61,970 typical · worth $47.1k
- Seattle, WA$61,500 typical · worth $46.4k
- San Jose, CA$61,940 typical · worth $45.5k
- San Francisco, CA$59,790 typical · worth $42k
All 50 metros for medical assistants →
Where does your salary land?
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Common questions
How much does a medical assistant make in St. Louis, MO?
The typical (median) medical assistant in the St. Louis, MO-IL metro area earns $44,710 a year. The middle half earn between $38,550 and $47,600, and the top 10% earn more than $48,620. Source: BLS Occupational Employment and Wage Statistics, May 2025.
What is a good salary for a medical assistant in St. Louis?
Anything above $44,710 pays more than half of medical assistants in St. Louis. $47,600 or more puts you in the top quarter, and $48,620 in the top 10%. Experience and employer move where you should be in that range.
How much does a medical assistant in St. Louis take home after taxes?
At the typical $44,710, a single filer keeps about $36,500 a year ($3,040 a month) after federal, Social Security, Medicare, Missouri state, and local income tax. With local prices 5% below the US average, that buys what $38,400 would in a typical US city.
Where do medical assistants get paid the most after cost of living?
Among the 50 largest US metros, typical medical assistant pay goes furthest after taxes and prices in Sacramento, CA, Seattle, WA, San Jose, CA. St. Louis, MO ranks No. 14.
More: Medical assistant pay in every large metro · Pay for other jobs in St. Louis, MO
Local prices: BEA regional price parities, 2024. Updated November 2026.